2. Fussball Bundesliga 2020/21 Liga
| 1 | 20.09.2020 11:30 | Holstein Kiel | – | SC Paderborn 07 | 1 : 0 | |
| 2 | 28.09.2020 18:30 | SC Paderborn 07 | – | Hamburger SV | 3 : 4 | |
| 3 | 03.10.2020 11:00 | 1. FC Heidenheim | – | SC Paderborn 07 | 0 : 0 | |
| 4 | 18.10.2020 11:30 | SC Paderborn 07 | – | Hannover 96 | 1 : 0 | |
| 5 | 25.10.2020 12:30 | SV Sandhausen | – | SC Paderborn 07 | 1 : 1 | |
| 6 | 31.10.2020 12:00 | SC Paderborn 07 | – | SSV Jahn Regensburg | 3 : 1 | |
| 7 | 08.11.2020 12:30 | SV Darmstadt 98 | – | SC Paderborn 07 | 0 : 4 | |
| 8 | 21.11.2020 12:00 | SC Paderborn 07 | – | FC St. Pauli | 2 : 0 | |
| 9 | 28.11.2020 12:00 | Karlsruher SC | – | SC Paderborn 07 | 1 : 0 | |
| 10 | 06.12.2020 12:30 | SC Paderborn 07 | – | 1. FC Nürnberg | 0 : 2 | |
| 11 | 11.12.2020 17:30 | VfL Bochum 1848 | – | SC Paderborn 07 | 3 : 0 | |
| 12 | 16.12.2020 17:30 | SC Paderborn 07 | – | Eintracht Braunschweig | 2 : 2 | |
| 13 | 19.12.2020 12:00 | VfL Osnabrück | – | SC Paderborn 07 | 0 : 1 | |
| 14 | 04.01.2021 19:30 | Fortuna Düsseldorf | – | SC Paderborn 07 | 2 : 1 | |
| 15 | 10.01.2021 12:30 | SC Paderborn 07 | – | FC Erzgebirge Aue | 2 : 1 | |
| 16 | 15.01.2021 17:30 | SpVgg Greuther Fürth | – | SC Paderborn 07 | 1 : 1 | |
| 17 | 23.01.2021 12:00 | SC Paderborn 07 | – | FC Würzburger Kickers | 1 : 0 | |
| 18 | 27.01.2021 19:30 | SC Paderborn 07 | – | Holstein Kiel | 1 : 1 | |
| 19 | 29.01.2021 12:00 | Hamburger SV | – | SC Paderborn 07 | 3 : 1 | |
| 20 | 23.02.2021 17:30 | SC Paderborn 07 | – | 1. FC Heidenheim | 2 : 2 | |
| 21 | 12.02.2021 17:30 | Hannover 96 | – | SC Paderborn 07 | 0 : 0 | |
| 22 | 20.02.2021 12:00 | SC Paderborn 07 | – | SV Sandhausen | 2 : 1 | |
| 23 | 26.02.2021 17:30 | SSV Jahn Regensburg | – | SC Paderborn 07 | 1 : 0 | |
| 24 | 05.03.2021 17:30 | SC Paderborn 07 | – | SV Darmstadt 98 | 2 : 3 | |
| 25 | 15.03.2021 19:30 | FC St. Pauli | – | SC Paderborn 07 | 0 : 2 | |
| 26 | 19.03.2021 17:30 | SC Paderborn 07 | – | Karlsruher SC | 2 : 2 | |
| 27 | 04.04.2021 11:30 | 1. FC Nürnberg | – | SC Paderborn 07 | 2 : 1 | |
| 28 | 10.04.2021 11:00 | SC Paderborn 07 | – | VfL Bochum 1848 | 3 : 0 | |
| 29 | 16.04.2021 16:30 | Eintracht Braunschweig | – | SC Paderborn 07 | 0 : 0 | |
| 30 | 21.04.2021 16:30 | SC Paderborn 07 | – | VfL Osnabrück | 2 : 2 | |
| 31 | 24.04.2021 11:00 | SC Paderborn 07 | – | Fortuna Düsseldorf | 2 : 1 | |
| 32 | 09.05.2021 11:30 | FC Erzgebirge Aue | – | SC Paderborn 07 | 3 : 8 | |
| 33 | 16.05.2021 13:30 | SC Paderborn 07 | – | SpVgg Greuther Fürth | 2 : 4 | |
| 34 | 23.05.2021 13:30 | FC Würzburger Kickers | – | SC Paderborn 07 | 1 : 1 |