2. Fussball Bundesliga 2020/21 Liga
| 1 | 19.09.2020 11:00 | Hannover 96 | – | Karlsruher SC | 2 : 0 | |
| 2 | 27.09.2020 11:30 | Karlsruher SC | – | VfL Bochum 1848 | 0 : 1 | |
| 3 | 03.10.2020 11:00 | SSV Jahn Regensburg | – | Karlsruher SC | 1 : 0 | |
| 4 | 17.10.2020 16:30 | Karlsruher SC | – | SV Sandhausen | 3 : 0 | |
| 5 | 23.10.2020 16:30 | 1. FC Nürnberg | – | Karlsruher SC | 1 : 1 | |
| 6 | 01.11.2020 12:30 | Karlsruher SC | – | SV Darmstadt 98 | 3 : 4 | |
| 7 | 08.11.2020 12:30 | FC St. Pauli | – | Karlsruher SC | 0 : 3 | |
| 8 | 21.11.2020 12:00 | Eintracht Braunschweig | – | Karlsruher SC | 1 : 3 | |
| 9 | 28.11.2020 12:00 | Karlsruher SC | – | SC Paderborn 07 | 1 : 0 | |
| 10 | 05.12.2020 12:00 | VfL Osnabrück | – | Karlsruher SC | 1 : 2 | |
| 11 | 13.12.2020 12:30 | Karlsruher SC | – | Fortuna Düsseldorf | 1 : 2 | |
| 12 | 17.12.2020 19:30 | FC Erzgebirge Aue | – | Karlsruher SC | 4 : 1 | |
| 13 | 21.12.2020 19:30 | Karlsruher SC | – | Hamburger SV | 1 : 2 | |
| 14 | 02.01.2021 12:00 | FC Würzburger Kickers | – | Karlsruher SC | 2 : 4 | |
| 15 | – | Karlsruher SC | – | SpVgg Greuther Fürth | 3 : 2 | |
| 16 | 17.01.2021 12:30 | Holstein Kiel | – | Karlsruher SC | 2 : 3 | |
| 17 | 23.01.2021 12:00 | Karlsruher SC | – | 1. FC Heidenheim | 1 : 1 | |
| 18 | 27.01.2021 19:30 | Karlsruher SC | – | Hannover 96 | 1 : 0 | |
| 19 | 31.01.2021 12:30 | VfL Bochum 1848 | – | Karlsruher SC | 1 : 2 | |
| 20 | 07.02.2021 12:30 | Karlsruher SC | – | SSV Jahn Regensburg | 0 : 0 | |
| 21 | 13.02.2021 12:00 | SV Sandhausen | – | Karlsruher SC | 2 : 3 | |
| 22 | 21.02.2021 12:30 | Karlsruher SC | – | 1. FC Nürnberg | 0 : 1 | |
| 23 | 26.02.2021 17:30 | SV Darmstadt 98 | – | Karlsruher SC | 0 : 1 | |
| 24 | 06.03.2021 12:00 | Karlsruher SC | – | FC St. Pauli | 0 : 0 | |
| 25 | 14.03.2021 12:30 | Karlsruher SC | – | Eintracht Braunschweig | 0 : 0 | |
| 26 | 19.03.2021 17:30 | SC Paderborn 07 | – | Karlsruher SC | 2 : 2 | |
| 27 | 03.04.2021 11:00 | Karlsruher SC | – | VfL Osnabrück | 0 : 1 | |
| 28 | 03.05.2021 18:30 | Fortuna Düsseldorf | – | Karlsruher SC | 3 : 2 | |
| 29 | 26.04.2021 16:30 | Karlsruher SC | – | FC Erzgebirge Aue | 0 : 0 | |
| 30 | 29.04.2021 16:30 | Hamburger SV | – | Karlsruher SC | 1 : 1 | |
| 31 | 23.04.2021 16:30 | Karlsruher SC | – | FC Würzburger Kickers | 2 : 2 | |
| 32 | 08.05.2021 11:00 | SpVgg Greuther Fürth | – | Karlsruher SC | 2 : 2 | |
| 33 | 16.05.2021 13:30 | Karlsruher SC | – | Holstein Kiel | 3 : 2 | |
| 34 | 23.05.2021 13:30 | 1. FC Heidenheim | – | Karlsruher SC | 1 : 2 |